Once you integrate the library, it can be Foundation or Bootstrap, you will not need to use the css grid nor flexbox rules, you simply give the corresponding classes to the documentation of these libraries so that it works.
For example in bootstrap if you want to make 4 columns, it's something like this:
<div class="container">
<div class="row">
<div class="col-md-4">Contenido</div>
<div class="col-md-4">Contenido</div>
<div class="col-md-4">Contenido</div>
<div class="col-md-4">Contenido</div>
</div>
</div>
And only with this HTML will you get 4 columns of equal size and responsive.
I hope my answer will help you.
Greetings!