Change menu with frameset to bootstrap

I have a website in which the front is divided with frameset, like this:

<FRAMESET name="fstMain" cols="*,980,*" border="0" frameborder="0" TOPMARGIN="0" LEFTMARGIN="0"
    MARGINHEIGHT="0" MARGINWIDTH="0" frameSpacing="0" onload="redirLocation();">
    <FRAME name="blanco" src="inicio.htm" scrolling="no" border="0" frameborder="no" noresize
        TOPMARGIN="0" LEFTMARGIN="0" MARGINHEIGHT="0" MARGINWIDTH="0">
    <FRAMESET id="fraMain" rows="102,*" border="0" FRAMESPACING="0" TOPMARGIN="0"
        LEFTMARGIN="0" MARGINHEIGHT="0" MARGINWIDTH="0">
        <FRAME name="fraToolbar" src="header.aspx" scrolling="no" border="0" frameborder="no" noresize
            TOPMARGIN="0" LEFTMARGIN="0" MARGINHEIGHT="0" MARGINWIDTH="0">
        <FRAMESET name="fstMain" cols="200,*" border="0" frameborder="0" FRAMESPACING="0" TOPMARGIN="0"
            LEFTMARGIN="0" MARGINHEIGHT="0" MARGINWIDTH="0">
            <FRAME src="Panelmenu.htm" LEFTMARGIN="0" MARGINHEIGHT="0" MARGINWIDTH="0" scrolling="no"
                >
            <FRAME name="fraRightFrame" src="Cuerpo.aspx" FRAMEBORDER="0" BORDER="0" BORDERCOLOR="#e1e9f6">
        </FRAMESET>
    </FRAMESET>
    <FRAME name="blanco" src="inicio.htm" scrolling="no" border="0" frameborder="no" noresize
        TOPMARGIN="0" LEFTMARGIN="0" MARGINHEIGHT="0" MARGINWIDTH="0">
</FRAMESET>

Now, they ask me if I can put something responsive, then I do not know if it is possible but I was thinking that the frame above and the frame of the left menu could be responsive, the body leave it like this because they are more than 1000 aspx, then the question would be, how can I make the frame above and the fram of the left menu make them responsive? Can only bootstrap be applied to these two frameset? or maybe someone can help me in the idea of responsive site or pretend a little that is responsive.