Fatal error: Unknown: Failed opening required in Unknown on line 0 Failed to upload URL from an image to a DB

I get an error when uploading the path of an image to a SQL database

 <?php
 session_start();

 $mysqli = new mysqli("localhost","root","1234","basededatos");


$Foto = $_FILES['foto']['name'];
$Tipo = $_FILES['foto']['type'];
$Ruta = $_FILES['foto']['tmp_name'];

echo $Foto.$Tipo.$Ruta;
$Destino = "../../Imagenes/FotosDePerfilesUsuarios/".$Foto;


if($Tipo == "image/jpg" || $Tipo == "image/png" || $Tipo == "image/gif" || 
$Tipo == "image/jpeg"){

        move_uploaded_file($Ruta,$Destino);

        $DestinoFinal = "Imagenes/FotosDePerfilesUsuarios/".$Foto;
        $ID = $_SESSION['ID'];

         $mysqli->query("UPDATE usuarios SET FotoPerfil = '$DestinoFinal' 
       WHERE ID = '$ID'");

       $_SESSION['FotoUsuario'] = $DestinoFinal;

       header('Location:http://localhost/Perfil.php');

       }else{
           header('Location:http://localhost');
       }
        ?>