I have an error with the runtime permissions

Hello friends I tell you that I have a problem, I have two buttons one allows me to access the microphone and the other save then I need two permissions, which work well to run the app leaves the sign asking for permission and all the problem is I can not use the buttons until I close and return to run the app I leave the structure I hope I get an orientation that I'm doing wrong.

 protected void onCreate(Bundle savedInstanceState) {
    super.onCreate(savedInstanceState);
    setContentView(R.layout.activity_main);

    if (ContextCompat.checkSelfPermission(getApplicationContext(), Manifest.permission.WRITE_EXTERNAL_STORAGE) != PackageManager.PERMISSION_GRANTED && ActivityCompat.checkSelfPermission(getApplicationContext(), Manifest.permission.RECORD_AUDIO) != PackageManager.PERMISSION_GRANTED) {
        ActivityCompat.requestPermissions(MainActivity.this, new String[]{Manifest.permission.WRITE_EXTERNAL_STORAGE, Manifest.permission.RECORD_AUDIO}, 1000);
    } else {                                    

      grabar.setOnClickListener(new View.OnClickListener() {
            @Override
            public void onClick(View v) {
                    Toast.makeText(getApplicationContext(), "La grabación comenzó", Toast.LENGTH_LONG).show();
            }
        });   
    guardar.setOnClickListener(new View.OnClickListener() {
            @Override
            public void onClick(View v) {

                    Toast.makeText(getApplicationContext(), "Se guardo", Toast.LENGTH_LONG).show();
            }
        });

    }
  }